Immunolocalization of Periostin-like Factor and Periostin During Embryogenesis

Role of Periostin/Periostin-Like-Factor in BMP-2 induced osteoblastic differentiation

Expression and function of periostin-like factor in vascular smooth muscle cells.

In injured blood vessels activated vascular smooth muscle cells (VSMCs) migrate from the media to the intima, proliferate and synthesize matrix proteins. This results in occlusion of the lumen and detrimental clinical manifestations. We have identified a novel isoform of the periostin family of proteins referred to as periostin-like factor (PLF). PLF expression in VSMCs was increased following ...

Periostin as a novel factor responsible for ventricular dilation.

BACKGROUND Periostin is highly expressed in the myocardium in patients with heart failure. However, no report has documented the function of periostin. To identify the function of periostin in the pathophysiology of heart failure, overexpression or loss of function of the periostin gene was examined by direct transfection into the rat heart. METHODS AND RESULTS Rats transfected with the perio...

Periostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair.

The matricellular protein periostin is expressed in the skin. Although periostin has been hypothesized to contribute to dermal homeostasis and repair, this has not been directly tested. To assess the contribution of periostin to dermal healing, 6 mm full-thickness excisional wounds were created in the skin of periostin-knockout and wild-type, sex-matched control mice. In wild-type mice, periost...

Periostin and myocardial repair, regeneration, and recovery.

Early reperfusion therapy for myocardial infarction has transformed the treatment of this disease. The restoration of blood flow to the heart within hours after thrombotic coronary occlusion reduces infarct size, maintains cardiac function, and minimizes the risk of late heart failure and lethal arrhythmias. However, high success rates of coronary reperfusion, coupled with aggressive efforts to...